1 FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AZITHROMYCIN USING NATURAL SUPERDISINTEGRANT

Abstract : The oral route remains the preferred route for administration of therapeutic agents because of accurate dosage, low cost therapy, self-medication, non-invasive method and ease of administration leading to high level of patient compliance. However, traditional tablets and capsules administered with a glass of water may be inconvenient or impractical for some geriatric patients because of changes in various physiological and neurological conditions. Therefore, to cater the needs of such patients, recent advancements in technology have resulted in development of viable dosage alternatives popularly known as mouth dissolving tablets. Mouth dissolving drug delivery is rapidly gaining acceptance as an important new drug delivery technology. Mouth dissolving tablets are fast disintegrating and/or dissolving rapidly in saliva before the need for water. Superdisintegrants provide quick disintegration due to combined effect of swelling and water absorption by the formulation. Mucilage of Plant ago Ovate has various characteristics like binding, disintegrating and sustaining properties. Therefore mucilage can be used as superdisintegrant to formulate fast dissolving tablets because it has very high percentage of swelling index. The present work was aimed to formulate the mouth dissolving tablet of Azithromycin by using natural superdisintegrants plant ago mucilage. The results from invitro disintegration time, invitro dissolution study, wetting time and water absorption ratio showed that the plant ago mucilage is more beneficial. Thus it can be concluded that natural superdisintegrant based more cheap mouth dissolving tablets of Azithromycin would be quite effective in treatment, by providing quick onset of action.

Keyword : Keywords: Azithromycin, mouth dissolving tablets, Plantago ovate, natural super disintegrant