1 The Molecular Classification of Women’s Breast Cancer by immunohistochemical, experience of Sidi Bel Abbes, Algeria.

Abstract : Breast cancer is the first cancer of women in Algeria but it remains a poorly known disease. Breast cancer is a heterogeneous disease from the clinical, histopathological and biological point of view with different prognoses and responses to different therapies. Traditional classifications including histological assessment and clinical staging are used to guide patient management. However, these prognostic and predictive factors are relatively crude measures and many patients are overtreated or undertreated as a result. Therefore, we propose, similarly to many series in the literature with 237 cases of invasive breast carcinoma (IBC) diagnosed at the Department of Pathology, Hospital-University-Center, Sidi Bel Abbes, Algeria, to address the new molecular classification of breast cancer by a conventional immunohistochemical (IHC ) approach, validated as a replacement technique for microarray analysis, which allows an individualisation of treatment. Our study showed 63.4% luminal tumors A, 10.5% luminal tumors B, 13.6% HER2 phenotype tumors, 12.5% of triple negative tumors whose 84.3% of normal-breast-like, 15.7% of non-basal-like tumors.

Keyword : Breast cancers, molecular classification, luminal, immunohistochemical.