Abstract : Objective: The present investigation aimed to study the protective effects of aqueous extract of Moringa olifera (MOR) leaf powder against the side effects of Adriamycin ADR (an anthracycline antibiotic, used in tumor therapy) on the hematological and biochemical functions of male albino rats. Animal's studies and drug treatment: 48 male albino rats weighing 180 ± 10.0 gm were taken and divided into six groups each one consists of 8 male rats. The 1st group was fed adlibitum with saline without any treatment so called control. The 2nd group received MOR leaf powder aqueous extract orally with a daily dose 144 mg/Kg body weight for 30 days. The 3rd one is ADR group where the animals were injected intraperitoneal (IP) from the first day in six equal injections of ADR (each containing 3 mg/kg b.wt.) over a period of two weeks (total cumulative dosage of 18 mg/kg body weight). The 4th is ADR then MOR post-treated group where animals administered the same six injections of ADR dose of thereafter they were given the aqueous MOR leaf powder extract orally from day 20. The 5th is ADR/MOR treated group where animals received six equal injections of ADR over a period of 19 days and given concomitant orally a daily dose of MOR leaf powder aqueous extract of 144 mg/kg of body weight for 30 days. The 6th group was (MOR pretreated then ADR group) where animals given orally once daily dose of MOR aqueous extract of 144 mg/Kg b.wt for 30 days and at the 11th day received the six equal injections of ADR over a period of 19 days. The results revealed loss in body weight, an increase in mortality rate, disturbances in hematological parameters, liver and kidney functions of rats treated with adriamycin. In contrast, the Moringa improves the studied parameters to levels more or less similar to that of control group. Conclusions: This study revealed that Moringa may ameliorate the effect of ADR especially in the group that pretreated with Moringa before Adriamycin treatment.

Keyword : Adriamycin, Moringa, Blood parameters, liver and kidney functions, histopathology, rats.

Abstract : ABSTRACT Thiriloga Chindhamani Pills (TCP) is commonly used in Siddha system of medicine for its analgesic, anti-inflammatory and anti-arthritic properties. However, these activities have not been scientifically validated through experimental procedures and clinical trials. So the present work was carried out to evaluate the above activities of TCP in rats. Hot Plate model was used to determine the analgesic activity. Two doses of TCP (100 mg and 200 mg/kg) was used and Diclofenac Sodium was used as standard. Among the two doses 200mg/kg showed highly significant analgesic activity indicated the analgesic activity of TCP in dose dependent manner. Evaluation of anti-inflammatory activity was carried out by carrageenan induced acute inflammatory model in rats. TCP100, TCP200 and reference drug Indomethacin was administered. The results showed that there was a significant difference in oedema size between all the tested groups. TCP 200 exhibited highly significant effect which is similar to that of standard drug. Evaluation of the antiarthritic activity of TCP was evaluated on Freund's complete adjuvant induced arthritic model. Two doses of TCP (100 and 200 mg / kg) and the reference drug Prednisolone 10mg/kg were administered. Both the positive control and two doses of Thiriloga Chindhamani Pills decreased the inflammatory process and TCP 200 significantly decrease the inflammation when compared to the control. This work has shown that Thiriloga Chindhamani Pills have analgesic, anti-inflammatory and anti-arthritic activities, which would justify their traditional use in Siddha system of medicine.

Keyword : Key words: Thiriloga Chindhamani Pills, Analgesic activity, Anti-inflammatory activity, Anti-arthritic activity