Abstract : Gels are transparent to opaque semisolid containing gelling agent that merges or entangles to form a three dimensional colloidal network structure. Its responsible for a gel resistance to deformation and its visco-elastic properties. Gels have better potential as a vehicle to administer rug topically in comparison to ointments because they are non-sticky, require low energy during formulation, have aesthetics value and are stable. The physical appearance was simply checked by colour, odour, taste. In this a homogeneity and texture of prepared gel was also determined. Viscosity was determine using Brookfeild digital viscometer. 5gm prepared gel sample was placed in sample holder of B. Viscometer using spindle no.6 at 25 0c and allowed it to settle for 5 min and viscosity measured by rotating it at different rpm. Antiheadlice activity was determined by using antibacterial method by diffusion assay or cylinder plat or cup- plate method.

Keyword : Diffusion assay, antiheadlice activity, antibacterial activity.

Abstract : The purpose of this study is to find an effective treatment without corneal haze in patients with high diopters and/or thin corneas; the idea is to offer them a safe surgical refractive treatment to improve their visual acuity (VA) without the use of intraocular implants for higher diopters avoiding therefore any associated risk. A retrospective, observational and descriptive case series included 75 eyes with ametropias with spherical equivalents the lowest -5.00 Diopters, the highest -22.00 Diopters who underwent photorefractive keratectomy. They were treated additionally with mitomycin 0.02%, contact lens, tobramycin/dexamethasone, and sodium hyaluronate for seven days. Upon removal of the contact lens, they were treated with glycerol 0.9% and sodium hyaluronate three times a day for two months. The 75 eyes included had a preoperative visual capacity was of 1.57 logMAR (SD 0.5), and postoperative of 0.1 logMAR (SD .12) (T test for paired samples, p=000) (FIGURE 2). Preoperative pachymetry was of 564.7 (SD 43.3) and postoperative of 449.1 micra (SD 55.9), (T test for paired samples, p=0.000). There were 5 cases of haze at the first postoperative month, no case of haze was presented at 3, 6 and 12 months of follow-up. This study shows that the use of glycerol is an effective treatment as an adjuvant to prevent haze; based on its osmolarity, hygroscopic capacity and its protein stabilizing properties.

Keyword : Glycerol, Hygroscopic, Haze, Keratocytes, Ametropia

Abstract : ABSTRACT The present work is an attempt to assess the in- vitro anthelmintic activity of the leaves and seed extracts of Caesalpinia decapetala (Roth). The crude drug was extracted in alcohol and water by using maceration extraction procedure. These extracts are used for assessment of in-vitro anthelmintic activity by using traditional earthworm technique. Doses of various concentration of extracts are prepared and earthworms are allowed to expose to them. Time of paralysis and death was observed and recorded as observations. In-vitro antihelmintic study of C. decepetala showed promising results. The perusal of the data reveals that the hydroalcoholic extract of the leaves at concentration of 10mg/ml, 20mg/ml, 40mg/ml, 50mg/ml and 100mg/ml showed paralysis and death time in 108, 63, 32, 15, 5& 138, 83, 48, 21, 11 mins. and the seed extract at same concentrations shows both paralysis and death at 63, 48, 25, 21, 4 and 87, 62, 32, 26, 9 mins respectively. Conclusion: The anthelmintic activity of leaves and seed plant extract of Caesalpinia decapetala (Roth) Alston. Was carried out on earth warm. Different concentrations of the hydroalcoholic extracts were used for the studies. The time taken for paralysis and death of earthworms were recorded. The extract showed paralysis followed by death of the worms at all tested dose levels.

Keyword : STH, Morbidity, Ayurveda, Anthelmintic, Earthworm method.

Abstract : Objective: To evaluate the effect of intravenous magnesium sulfate on post-operative complications when given prophylactically while coming of cardio pulmonary bypass (CPB) in patients undergoing cardiac surgery. Methodology: A double-blinded randomized studyconducted at a tertiary care center in western Maharashtra from Nov 2017 to April 2019. Patients were divided into two groups. Group A (Magnesium sulfate group) (n=130) & Group B (control group) (n=130). Patients undergoing on pump Coronary artery bypass grafting (CABG), Mitral valve replacement/repair (MVR), Aortic Valve Replacement (AVR) or both AVR & MVR (DVR) on CPB were included in the study.Once surgery was over, aortic cross clamp taken out & temperature of 36°c was attained, Group A patients received Injection Magnesium sulfate 1 gm IV slowly over 10 minutes.Patients were monitored for heart rate, intra-arterial blood pressure oxygen saturation, continuous electrocardiograph with automatic ST segment analysis apart from this ECG mapping was done. Results:There was no significant Statistical difference regarding the demographic data, comorbidities & ejection fraction between the two groups. The result shows a statistically significant difference (P=0.032) between the two groups with regards to the incidence of atrial fibrillation. In group A 10 patients (7.70%) had atrial fibrillation compared to group B where 28 patients (21.6%) had atrial fibrillation.Weaning from CPB was easier in group A patient compared to group B & also group A patient needed smaller doses of pharmalogical support, than group B. Conclusion: A single bolus 1Gm dose of magnesium sulfate while coming off from CPB has an excellent effect in reducing the incidence of atrial fibrillation. Further magnesium reduced the amount of pharmacological support which was required to come off CPB.

Keyword : CABG: Coronary artery bypass grafting, MVR: Mitral valve replacement/ repair, AVR: Aortic valve replacement, DVR: Dual valve replacement, IABP: Intra-aortic balloon pump,CPB:Cardio-Pulmonary Bypass.