Archive : Volume - 6, Issue - 8, Month - August
1 PHYTOCHEMICAL INVESTIGATION AND IN VITRO BIOACTIVITY ANALYSIS OF LINDENBERGIA INDICA
- Farina Aziz* ,
- Sheikh Nazrul Islam ,
- Muhammad Abdullah Al-Mansur ,
- Monira Ahsan ,
- Choudhury Mahmood Hasan
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- Journal DOI : 10.46624/bjmhr.2019.v6.i08.001
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Abstract : Lidenbergia indica Vatke or wall lindenbergia belongs to the family Scrophulariaceae which includes a number of ethnopharmacologically important Himalayan medicinal plants. The juice of the plant is used in chronic bronchitis and skin eruptions. The crude ethyl acetate extract of the whole plants of Lidenbergia indica led to the isolation of two flavonoids, luteolin and apigenin, methyl-4-methoxy cinnamate and β-sitosterol by different chromatographic techniques. The petroleum ether, chloroform, ethyl acetate and aqueous fractions were evaluated for biological properties using established methods. In vitro antioxidant activity was studied with DPPH radical scavenging method using butylated hydroxyl anisole as standard. The ethyl acetate fraction of the plant showed prominent free radical scavenging activity. The petroleum ether soluble fraction of Lindenbergia indica demonstrated highest thrombolytic activity. However, the other partitionates i.e. chloroform, ethyl acetate and aqueous extract showed minimum thrombolytic activity compared to the standard streptokinase. In the cytotoxic activity assay using brine shrimp, the petroleum ether, chloroform and ethyl acetate fraction showed significant lethality whereas aqueous fraction showed negligible lethal activity as compared to standard vincristine sulphate. No antimicrobial activity was observed for the petroleum ether, chloroform, ethyl acetate and aqueous fractions against all the microorganisms tested using tetracycline, levofloxacin, azithromycin and ciprofloxacin as standard.
Keyword : Lidenbergia indica, Scrophulariaceae, Luteolin, Apigenin, Methyl-4-methoxy cinnamate, Antioxidant.
2 PROTECTIVE EFFECT OF L-CARNITINE AGAINST REPRODUCTIVE TOXICITY OF MONOSODIUM GLUTAMATE IN MALE ALBINO MICE
- Ahmad Ali Kandeel* ,
- Abd-El-karim Mohamed Abd-Lateif ,
- Wessam Salim Tawfik ,
- Khalid Haussen Zaghloul
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- Journal DOI : 10.46624/bjmhr.2019.v6.i08.002
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Abstract : Monosodium glutamate (MSG) is a commonly used food enhancer which causes a wide range of toxic effects including reduced male fertility. This study was carried out to investigate the protective effect of L-carnitine against monosodium glutamate (MSG)-induced testicular toxicity in adult male mice. Sixty adult male albino mice (age 10 weeks) were used in the present study and divided into six groups. Group I used as control group (10 mice). Group II (10 mice) received 150 mg/kg/day L-carnitine. Group III& IV (10 mice each) was received 0.3 and 0.6 mg MSG/g body weight. Group V and VI (10 mice each) received 0.3 and 0.6 mg MSG /g body with 150 mg L-carnitine/kg body weight. All animals were treated orally by gastric intubation for 35 days. Reproductive performance, gonadosomatic index (GSI), sperm count, motility, and morphology as well as comet assay were studied. The study demonstrated that L-carnitine ameliorated MSG alterations in testicular weight, sperm count, sperm motility, and sperm morphology together with DNA degradation. This study indicated that the treatment of mice with L-carnitine enhances MSG reproductive toxicity by improving sperm quality and DNA status.
Keyword : Glutamate, Mice, Sperm, Reproductive Toxicity, L-carnitine.
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