Abstract : ABSTRACT From 2019, the world has faced the pandemic of high severity ever inexperienced: COVID 19. It has called the efforts of various stakeholders for prevention of its propagation, treatment of infected persons, limitation of its effects, etc. Healthcare workers have been at the forefront of response to COVID-19, risking their lives and their physical and mental health. Despite many efforts to improve the overall quality of healthcare service delivery during COVID-19 era, a number of patients reported to receive inadequate healthcare service. The objective of this research was to understand factors associated with the quality of healthcare service delivery, especially those linked to COVID-19 pandemic. Findings of research will contribute on the efforts for effective strategies for quality assurance in healthcare services delivery. This research was conducted in Kigali City, Southern and Eastern provinces of Rwanda, from January to April 2022. 385 respondents were identified among healthcare service providers and beneficiaries of those services. Data was collected using a questionnaire and interview guide. Quantitative data collected using a questionnaire was analyzed using SPSS version 22. On the other hand, qualitative data collected through interviews was analyzed using thematic analysis method. Results from data analysis were discussed before addressing conclusion and recommendations. The big proportion of healthcare service providers (56%) and beneficiaries (61%) ranked healthcare service delivery as good, while 78.6% of beneficiaries and 100% of healthcare service providers confirmed that they have observed the change in healthcare service delivery during this COVID-19 era. The great change was reported by 3.6% of beneficiaries, while only 17.8% of beneficiaries have not observed the change. The quality of healthcare service delivery has not been affected at the same level in all health institutions. The increased workload in health sector has been mentioned as the main factor which has strongly affected healthcare service delivery in public hospitals and health centers, while lockdowns have particularly affected healthcare service delivery for beneficiaries of referral hospitals. Specific short-term, medium-term, and long-term recommendations to strengthen health system or accessible high quality health care services during and after COVID-19 era were addressed. Keywords: COVID-19, SARS-COV-2, healthcare, healthcare service delivery

Keyword : COVID-19, SARS-COV-2, healthcare, healthcare service delivery

Abstract : Genetic diseases are chronic in nature and very problematic. The aim of this study was to determine the impacts of genetic diseases on the affected children’s parents in the African region. A scoping review of eleven electronic databases was done. Only original peer-reviewed qualitative research studies published in peer-reviewed journals and periodicals published in English language between 2018 and 2022 were included. Thematic content analysis and synthesis was employed to analyze and present the findings. Out of 4765 identified articles, only 12 studies fully met the inclusion criteria. The study concluded that parents of children with genetic diseases face many challenges such as; (i) low quality of life—physically, socially, psychologically and environmentally; (ii) lack of information; (iii) lack of specialized services; (iv) financial strain; (v) negative or inappropriate coping mechanisms; and (vi) existential concerns. The study recommends that; (i) counselling and social support for affected parents to help mitigate the impact of genetic diseases; (ii) raising awareness of genetic diseases among the affected parents and their families, as well as the public in general; (iii) international and national policies and programmes should be instituted to enhance screening and detection of genetic disorders, coordination of clinical management of genetic diseases, facilitation of training of medical genetics/genomics professionals, and the stimulation of research in genetic diseases; (iv) ensure affordability of treatment and healthcare services to parents with children with genetic diseases; (v) promote resilience and positive adaptive coping mechanisms; and (vi) provision of trauma counselling to the affected parents.

Keyword : Genetic diseases, children, parents, Africa.

Abstract : ABSTRACT Cyclin D dependent kinases namely CDK4 and CDK6 regulate entry into S phase of the cell cycle. These are emerging validated targets for anti-cancer drug discovery. A QSAR study has been carried out on the 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives, which were reported as highly potent and selective inhibitors of CDK4 and CDK6, in terms of Dragon descriptors with the aim to establish the quantitative relationships between the reported activities and molecular descriptors unfolding the substitutional changes. In deriving QSAR models, combinatorial protocol in multiple linear regression (CP-MLR) approach was used. These models have accounted for nearly 79 and 83% variance in the CDK4 and CDK6 observed activities, respectively. The statistically validated QSAR models and the descriptors emerged in these models provided rationales to explain the CDK4 and CDK6 inhibitory activities of these congeners. PLS analysis has also corroborated the dominance of CP-MLR identified descriptors. Applicability domain analysis revealed that the suggested model matches the high quality parameters with good fitting power and the capability of assessing external data and all of the compounds was within the applicability domain of the proposed model and were evaluated correctly. Keywords: QSAR, CDK4 and CDK6 inhibitors, Combinatorial protocol in multiple linear regression (CP-MLR) analysis, PLS, Dragon descriptors, 4-Thiazol-N-(pyridin-2-yl) pyrimidin-2-amines.

Keyword : QSAR, CDK4 and CDK6 inhibitors, Combinatorial protocol in multiple linear regression (CP-MLR) analysis, PLS, Dragon descriptors, 4-Thiazol-N-(pyridin-2-yl) pyrimidin-2-amines.