Archive : Volume - 2, Issue - 4, Month - April
1 ROSUVASTATIN: A REVIEW OF PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES
- Syed A Rabbani* ,
- Syed M AlI
- Abstract
- Show Article
- Download : 208
- Certificate
Abstract : Rosuvastatin is a potent statin with pharmacologic and pharmacokinetic advantages. Its high degree of liver selectivity results in high hepatic concentration leading to superior efficacy at lowering low density lipoprotein cholesterol and triglycerides as well as improving high density lipoprotein cholesterol compared to other statins. Rosuvastatin has relatively low lipophilicity when compared with other statins and has minimal entry into peripheral cells. This along with its minimal cytochrome P450 metabolism presents relatively better tolerability, safety and drug interaction profile. Consistent with these features, rosuvastatin represents a step forward in the statin therapy. We conducted a literature search to identify rosuvastatin papers published in English. In this review, we have outlined the pharmacodynamics, pharmacokinetics of rosuvastatin, focusingits efficacy and safety. We have also emphasized on the major clinical trials involving rosuvastatin.
Keyword : rosuvastatin, pharmacodynamics, pharmacokinetics
2 Serum Lead and Phosphorus Levels in Sudanese Pregnant Woman with Preeclampsia
- AbdElkarim A Abdrabo* ,
- Fadwa Y AL Madani ,
- Gad A Modawe
- Abstract
- Show Article
- Download : 181
- Certificate
Abstract : Preeclampsia is one of the causes that lead to mortality among pregnant woman and fetus. However it is etiology is unknown. The objective of this study was to assess the level of serum lead and it is relation with serum phosphorus in the development of preeclampsia. This study was case control hospital based study, Blood samples were collected from 50 preeclamptics, 50 normal pregnant women. Serum lead was determined using atomic absorption spectrophotometer and serum Phosphorus was determined by using spectrophotometer. The study was conducted during the period of January to April 2015. The mean ±SD of serum lead and phosphorus respectively were(0.98±0.26, 3.98±0.81) for preeclampsia ,while the mean±SD of serum lead and phosphorus respectively in normal pregnant women were(0.32±0.11, 3.6±.66 ). lead was significantly higher(p=0.00) , whereas Phosphorus was significantly lower (p =0.03) in preeclamptics than in normal pregnant women Also serum lead was positively correlated with systolic and diastolic blood pressures(p=0.01) in preeclampsia. Preeclamptics have a higher serum lead and lower serum phosphorus levels when compared with normal pregnant women. It appears that increase in serum lead, which parallel decreases in serum phosphorus, may be related to the development of preeclampsia.
Keyword : Preeclampsia, pregnant women, Serum lead, serum phosphorus, Sudanese.
3 A Study of Prevalence of High Blood Pressure Among Young Adults in Goa: Uncovering a Silent Epidemic
- Premanandh K* ,
- A M Ferreira ,
- F S Vaz ,
- M S Kulkarni ,
- S G Perni ,
- U S Kamat ,
- N R Pinto
- Abstract
- Show Article
- Download : 183
- Certificate
Abstract : The prevalence of hypertension is rapidly increasing in India, both in urban and rural areas. The increase in incidence in hypertension at a younger age is essentially due to lifestyle factors. Given the rising prevalence of hypertension among young adults in developing countries early detection and treatment of high blood pressure is essential to the reduction of cardiovascular disease and prevention of associated burden of illness. The cross sectional study was conducted in a rural area in Goa among young adults in the age group 20-39 years. The study participants were interviewed with a structured pretested questionnaire. The three sections of the questionnaire included demographic variables, behavioural risk factors and physical measurements and examination. The data was entered and analysed using the SPSS software package. Bivariate analysis was performed to establish the association between the various factors and hypertension. Odds ratio was calculated with 95% confidence interval. Stepwise logistic regression analysis was used to identify independent predictors of hypertension. The prevalence of hypertension was found to be 13.7% among young adults in the study area. The prevalence was higher among males (16.5%) compared to females (10.8%). On bivariate analysis; smoking, alcohol use, physical inactivity, obesity, family history of hypertension were identified as significant risk factors of hypertension. Multiple logistic regression identified alcohol consumption, insufficient physical activity and abdominal obesity as the most significantly associated factors for hypertension. Hypertension to a great extent is a preventable disease hence appropriate preventive action can alter environments, protect against risk factors and change life expectations. On a population scale, relatively modest behavioural changes affecting several of the risk factors simultaneously can make dramatic changes in population health.
Keyword : Hypertension, prevalence, risk factors, young adults.
Login
Loading....
Author Guideline
Copyright Form
News Update
Archive List
- Volume-11
- Volume-10
- January 2023 Issue 1
- January 2023 Issue 1
- February 2023 Issue 2
- March 2023 Issue 3
- March 2023 Issue 3
- April 2023 Issue 4
- April 2023 Issue 4
- May 2023 Issue 5
- May 2023 Issue 5
- May 2023 Issue 5
- June 2023 Issue 6
- June 2023 Issue 6
- July 2023 Issue 7
- July 2023 Issue 7
- August 2023 Issue 8
- August 2023 Issue 8
- September 2023 Issue 9
- October 2023 Issue 10
- November 2023 Issue 11
- December 2023 Issue 12
- Volume-9
- January 2022 Issue 1
- February 2022 Issue 2
- March 2022 Issue 3
- April 2022 Issue 4
- May 2022 Issue 5
- June 2022 Issue 6
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- August 2022 Issue 8
- September 2022 Issue 9
- October 2022 Issue 10
- October 2022 Issue 10
- November 2022 Issue 11
- November 2022 Issue 11
- November 2022 Issue 11
- December 2022 Issue 12
- Volume-8
- January 2021 Issue 1
- February 2021 Issue 2
- February 2021 Issue 2
- March 2021 Issue 3
- April 2021 Issue 4
- May 2021 Issue 5
- June 2021 Issue 6
- June 2021 Issue 6
- June 2021 Issue 6
- July 2021 Issue 7
- August 2021 Issue 8
- September 2021 Issue 9
- October 2021 Issue 10
- November 2021 Issue 11
- December 2021 Issue 12
- Volume-7
- January 2020 Issue 1
- January 2020 Issue 1
- February 2020 Issue 2
- March 2020 Issue 3
- March 2020 Issue 3
- March 2020 Issue 3
- April 2020 Issue 4
- April 2020 Issue 4
- May 2020 Issue 5
- May 2020 Issue 5
- May 2020 Issue 5
- June 2020 Issue 6
- June 2020 Issue 6
- June 2020 Issue 6
- July 2020 Issue 7
- August 2020 Issue 8
- September 2020 Issue 9
- October 2020 Issue 10
- November 2020 Issue 11
- December 2020 Issue 12
- December 2020 Issue 12
- Volume-6
- January 2019 Issue 1
- February 2019 Issue 2
- March 2019 Issue 3
- April 2019 Issue 4
- April 2019 Issue 4
- May 2019 Issue 5
- May 2019 Issue 5
- June 2019 Issue 6
- June 2019 Issue 6
- July 2019 Issue 7
- July 2019 Issue 7
- August 2019 Issue 8
- September 2019 Issue 9
- September 2019 Issue 9
- September 2019 Issue 9
- October 2019 Issue 10
- November 2019 Issue 11
- November 2019 Issue 11
- November 2019 Issue 11
- December 2019 Issue 12
- Volume-5
- January 2018 Issue 1
- January 2018 Issue 1
- February 2018 Issue 2
- March 2018 Issue 3
- April 2018 Issue 4
- May 2018 Issue 5
- June 2018 Issue 6
- July 2018 Issue 7
- August 2018 Issue 8
- September 2018 Issue 9
- September 2018 Issue 9
- October 2018 Issue 10
- October 2018 Issue 10
- November 2018 Issue 11
- December 2018 Issue 12
- December 2018 Issue 12
- Volume-4
- January 2017 Issue 1
- February 2017 Issue 2
- February 2017 Issue 2
- March 2017 Issue 3
- April 2017 Issue 4
- April 2017 Issue 4
- May 2017 Issue 5
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- July 2017 Issue 7
- August 2017 Issue 8
- August 2017 Issue 8
- September 2017 Issue 9
- October 2017 Issue 10
- November 2017 Issue 11
- December 2017 Issue 12
- December 2017 Issue 12
- December 2017 Issue 12
- Volume-3
- January 2016 Issue 1
- February 2016 Issue 2
- March 2016 Issue 3
- April 2016 Issue 4
- May 2016 Issue 5
- June 2016 Issue 6
- June 2016 Issue 6
- July 2016 Issue 7
- July 2016 Issue 7
- July 2016 Issue 7
- August 2016 Issue 8
- September 2016 Issue 9
- October 2016 Issue 10
- October 2016 Issue 10
- November 2016 Issue 11
- November 2016 Issue 11
- December 2016 Issue 12
- Volume-2
- Volume-1
Statastics
Download of Articles
107,992