Archive : Volume - 4, Issue - 9, Month - September
1 PREDISPOSING FACTORS OF THE PSORIATIC DISEASE
- Stoyan Ivanov Pavlov*
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Abstract : The psoriasis is a chronic inflammatory immune-mediated, proliferative skin disease, that can involve the skin, nails and joints, affecting 1 to 3% of the population. The triggering factors (local trauma, drugs, infectious, psycho emotional stress, smoking), that may provoke psoriatic disease are an object of systemic and thorough studies and also include the family predisposition and immune mechanisms of the inflammatory process, leading to development of psoriatic plaques. The essential role is possessed by the genetic predisposition, followed by the immune disturbances, that can trigger a chronic inflammation, damaging the skin and joints. The final steps leading to psoriatic disease are the disturbed proliferation and differentiation of the keratinocytes. The antimicrobial peptides are acting like mediators of inflammation process. Their role is also to attract immune cells, in order to produce active cytokines. The antimicrobial peptide cathelicidin LL-37 is capable to connect the derived DNAs and RNAs in the cytosol from the damaged epithelial cells and to present them to the dendritic cells, triggering the inflammatory chain, therefore cathelicidin is a subject of further studies, aimed to found a factor, that consolidate all other triggers of the disease.
Keyword : psoriasis, cathelicidin, triggering factors
2 Triple Negative Breast Cancer Association With Basal Molecular Subtype In The Middle Of Iraq
- Emad Alwan Alsaabery* ,
- Zuhair . Alleban ,
- Hashim . Raheem ,
- Hawraa Ameer Mubark
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Abstract : The study aim to determine the role of vitamin D and BMI in basal expression of TNBC patient. TNBCs are a diverse set of tumors with one usual clinical character, a markedly aggressive behavior, greater proportions of relapse, lesser overall survival in the disseminating cases matched with further groups of breast malignancy. Cytokeratin 5/6 proteins are important in the classification of tumor cells as basal type. The current study was designed to determine the percentage of basal type by examination of cytokeratiein 5/6 and determining the role of BMI in the basal expression of patients with triple-negative breast cancer. Triple-negative cancer was diagnosed in Al-Sadr Teaching Hospital in AL- Najaf by a pathologist. cytokeratiein 5/6was determined by using the immunohistochemistry method. The WHO classification was determined to measure the body mass index. The number of patients involved was 70 patients. The study founded that the percentage of basal cancer was (77.1%) 54 and found a significant statistical difference in the age of menarche between basal type with other breast cancer subtype and there are no differences of statistical significance in the basal type and other cancer with subtype in tumor site and menopausal state and in BMI, The study concluded that basal subtype was more common than luminal subtype in studied TNBC and basal subtype of TNBC is associated significantly with age of menarche.
Keyword : breast cancer, cytokeratin 5/6, body mass index.
3 Landscape Analysis of the Engagement of Private Sector In Achieving Universal Health Coverage In Nigeria and the Policy Implications
- Oladimeji . OJ* ,
- Gillespie . J
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Abstract : Global efforts in health over the last decade have been towards achieving universal coverage for all populations. Quality health service and financial protection are vital component in the implementation of UHC in any country, though its specific framework differs depending on the context of the country. Public sector involvement in the achievement of this cannot be over emphasized but the role of the Private Health sector in achieving UHC in developing countries has rarely been well understood. This is because in most low-income and middle-income countries (LMICs) which include Nigeria, the sector is generally large, poorly documented, and very heterogeneous, and extremely profit oriented. This study used the landscape analysis approach which examines an existing system and the multiple factors of the system which can indicate preparedness of the system for an intervention. This landscape analysis is aimed at exploring the existing structure of Private sector in healthcare in Nigeria and how the structure shapes the sector’s engagement in the achievement of UHC in Nigeria. It explored the various groups that make the Private Health sector in Nigeria, their characteristics and how these characters shape their involvement in the progress towards universal health coverage in Nigeria. Furthermore, it used a framework to link systemic factors in Nigeria with the Private health sector and UHC in Nigeria. Finally, it recommends a policy strategy and feasibility on how the Private Health sector can be integrated into the health system to harness its benefits for the progress towards UHC in Nigeria.
Keyword : Landscape Analysis, Private health sector and UHC
4 TOXOPLASMOSIS AMONG PREGNANT AND NON-PREGNANT WOMEN ATTENDING AL-SHIFA HOSPITAL IN GAZA STRIP, PALESTINE
- Adnan Ibrahim Al-Hindi* ,
- Majdal Jehad Madhon ,
- Doaa N Abo-Karsh ,
- Asmaa O Mansor
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Abstract : The aim our study is to study the occurrence of toxoplasmosis among pregnant and non-pregnant in Gaza strip. In cross-sectional study 164 sample was collected from pregnant and non pregnant woman attending Al-shifa hospital. Quantitative investigation of each blood sample for the levels of the specific IgG and IgM of T.gondii was done for collected sample. The overall prevalence of Toxoplasma IgG was found 33.2% and Toxoplasma. IgM was found to be 21%.
The highest rate of IgG (47.4%) was in age group from 35-45 years old and IgM was (40%) in age group 25 to 35 years old. The women residing in the East Gaza city had IgG (42.2%) but in IgM was(32.1%) in the women residing in the North and Midzone. The highest rate of IgG (57.1%) and IgM (42.9%) were noticed among the employed women.
In conclusion the result of this study shows a significant high seroprevalence of toxoplasmosis infection in pregnant women, and an important association with different socioeconomic factors.
It is recommended that Toxoplasma gondii should applied as a routine test in Gaza and further studies to determine the reality of the definitive host infection (cats) in Gaza.
Keyword : Toxoplasma, pregnant, prevalence, diagnosis, Gaza
5 Influence of Knowledge, Attitudes and Access of Contraceptive Methods on Unmet Need for Family Planning Among Women of Reproductive Age in Rubavu District, Rwanda.
- BIKORIMANA Emmanuel*
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Abstract : ABSTRACT
Background: While achievements have been gained with modern contraceptive use rising from 10% in 2005 to 47.5% in 2015 with a resultant fall in fertility from 6.1 children per woman to 4.2 children in Rwanda, there remain some challenges. The current study identified the influence of knowledge, attitude, accessibility and availability of contraceptive methods on unmet need for family planning among women of reproductive age in Rubavu District, Rwanda.
Methods: A cross-sectional study was carried among 270 women (15–49 years) attending public health facilities in western province, Rubavu district. Semi-structured questionnaires were used to measure knowledge, attitudes and accessibility of contraceptive methods. The outcome variable was unmet need for family planning (unmet need for spacing and limiting births).Bivariate analysis was done for the independent variable with the dependent variable then multiple logistic regressions was computed. To identify the independent effects of independent variables to unmet need for contraception, the Odds Ratio (OR) with 95% confidence interval was computed and statistical significance was defined when p-value was less than 0.05.
Results: The overall prevalence of unmet was 46.6% (Unmet need for spacing 27.78% and unmet need for limiting 18.9%). After adjusting for other variables, contraceptive methods improve standard of life (OR = 0.445, 95 % CI =0.222-0.092 , P =0.023 , Family Planning (F P) methods cause weakness (OR = 2.879, 95 % CI =1.428-5.805, P =0.003; joint decision to use FP (OR =0.472 , 95 % CI =0.286-0.778 , P =0.003 ), decision to use FP taken by husband (OR =2.703 , 95 % CI =1.320-5.536 , P =0.007 , were significantly associated with unmet for spacing . While FP methods cause headache (OR = 2.240, 95 % CI =1.068-4.696, P =0.033 joint decision to use FP (OR =0.561, 95 % CI =0.367-0.858, P =0.008), decision to use FP taken by husband (OR =2.283, 95 % CI =1.078-4.856, P =0.032 for unmet need for limiting)
Conclusion: The attitudes that FP methods cause weakness, FP methods cause headache and decision to use FP taken by husband increase unmet need for family planning.
Keyword : Knowledge, Attitude, Access, Contraception, Unmet Need for Family Planning, Women of Reproductive Age.
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