Archive : Volume - 9, Issue - 4, Month - April
1 Various Synthetic Pathways of Flavanones Focused on their Biological Activity: A Review
- Somashekhar Metri* ,
- Basavraj Dashyal ,
- Sammed Melvanki ,
- Maharani B ,
- Md Iliyas ,
- R B Kotnal
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- Journal DOI : 10.5281/zenodo.6937702
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Abstract : ABSTRACT
Flavanones are a diverse group of phytonutrients found in most plants. They act as pigments, producing many colours like yellow, red and orange found in plant-based diets. Flavanones have become an essential component in a wide range of nutraceutical, pharmacological, therapeutic, and cosmetic applications. This is due to their ability to control critical cellular enzyme activity as well as their anti-inflammatory, Flavanones were discovered in 1938 by a Hungarian scientist named Dr. Albert Szent-Gyorgyi, who identified them as vitamin P. The challenge is that the chemistry of Flavanones is difficult because there are over 6,000 distinct compounds that belong to the flavonoid family. These challenges could be overcome by optimization techniques, novel technology, fermentation and metabolic engineering. The functional recommendations that could be added here are population heterogeneity, high study cost and time. Many different chemical families of compounds such as Flavonols, dihydroflavonols, flavones, isoflavones, flavanones, anthocyanins, and anthocyanidins are among these groups. Hundreds, if not thousands, of distinct Flavanones can be found in each of these families. Examples of some well-known flavonols include quercetin, rutin, and hesperidin while well-known apigenin and luteolin.
Keywords: Flavanones, Antimicrobial activity, Anticancer activity, Bio Flavanones, Antibacterial characteristics.
Keyword : Flavanones, Antimicrobial activity, Anticancer activity, Bio Flavanones, Antibacterial characteristics.
2 Acromegaly in Young
- Kshitij Sanjay Kumat ,
- Dharmendra Janardanrai Vatsaraj* ,
- Siddharth Kaushik Shah ,
- Deepali Vijay Lodha
- Abstract
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- Journal DOI : 10.5281/zenodo.6937791
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Abstract : Acromegaly is a rare,slowly progressive disease caused by chronic hypersecretion of growth hormone (GH) and excess circulating insulin-like growth factor-1 (IGF-1). The etiology of acromegaly is almost invariably an underlying GH-secreting pituitary adenoma. Rarely, it is due to a hypothalamic tumor secreting GHRH or ectopic growth hormone releasing hormone (GHRH) secretion, or very rarely GH from an ectopic source. We are here reporting a case of 21 yrs old female who presented with headache and amenorrhea since 1 year which on investigating patient had Acromegaly due to Pituitary Adenoma. Therapy for Acromegaly is targeted at decreasing GH and IGF-1 levels, ameliorating patients symptoms and decreasing any local compressive effects of the pituitary adenoma. The therapeutic options for acromegaly include surgery, medical therapies(dopamine agonists, somatostatin receptor agonists and the GH receptor antagonist) and radiotherapy. A multi disciplinary approach is recommended with often a requirement for combined treatment modalities. With disease control, associated morbidity and mortality can be reduced
Keyword : Acromegaly in Young, Pituitary Adenoma
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